Check out the wiki for faqs and details about the different settings.Default league is set to tmpstandard (current Softcore Temp-League), you can change this by right-clicking on the system tray icon > PoE (Trade) Item Info Settings or using the appropriate shortcut.
Make sure to run PoE in (borderless) windowed mode.Download the latest release and extract the zip-file.PSA: If AHK crashes when starting TradeMacro try and use a different version, AutoHotkey_1.1.26.01 should always work. When in doubt ask other people or do some manual checks. Use the tools average and median prices to quickly judge if the first results could be accurate or totally wrong. Inform yourself about what this tool can do and what not ( FAQ for example).
Never completely trust any price checking tool. This includes automatic price check macro. PoE-TradeMacro is an Autohotkey (AHK) script that provides several convenient QoL features for Path of Exile Trading.